Personally I'd expect Old Humanity enclaves to look like Brazil with even more mixing and 'anime' colors added in. Though the skin cancer thing might continue to select for darker skin in the sun-rich regions... assuming Old H doesn't have other anti-cancer mechanisms engineered in. Conversely, they might make their own vitamin D, with white skin having largely vanished. You can justify anything really, though I think adding exciting new colors or other aesthetic traits is probably almost certain; adding harmless pigments seems the easiest thing to do with human genetic engineering.

We know human evolution can happen in a few millennia or less, when it comes to disease resistance traits or lactose tolerance, and of course evolution is faster when adjust gene frequencies rather than building new complex organs or adaptations. I don't know when the Lifemakers vanished, but there's probably room to say "they were designed for personality X but post-collapse selection has changed things somewhat".

Of course, as I note in another comment, differences in life cycle or senses can cause robust differences. Stronger for the uplifted animals.

(Polarized vision. Electric or magnetic field senses. Magnetite deposits in fingertips. Four-color vision. Echolocation. Different art, at least... of course what's fun for SF worldbuilding may not be good gaming.)